The game was followed in October 2008 by Spider-Man: Web of Shadows, which has no connections to the Spider-Man film series. The drastic differences between platforms was another point of criticism. Most of the criticism was aimed at the game's graphics, short length, and technical issues, as well as being too similar to its predecessors. With the exception of the Nintendo DS version, which received mostly positive reviews, Spider-Man 3 was met with a mixed critical response. Bruce Campbell, who played a French maître d' in the film, narrates the game's tutorial level.

Most actors reprise their roles from the film, including Tobey Maguire, James Franco, Topher Grace, Thomas Haden Church, and J. While the game directly adapts the plot of the film, it builds upon it by including additional characters and elements from the Spider-Man comic books and other aspects of the Marvel Universe. The symbiote costume from the film is a major gameplay mechanic, increasing Spider-Man's strength and unlocking new abilities. The game plays similarly to two of Treyarch's previous Spider-Man titles, Spider-Man 2 and Ultimate Spider-Man, incorporating an open world design that allows players to freely explore a fictitious representation of Manhattan when not completing missions to advance the narrative. Beenox ported Treyarch's version of the game to Windows. Published by Activision, the Xbox 360 and PlayStation 3 versions were developed by Treyarch, while Vicarious Visions handled the development of the other versions, which are drastically different. Made to promote the film of the same name, it was released for Microsoft Windows, Xbox 360, PlayStation 3, PlayStation 2, Wii, Nintendo DS, and Game Boy Advance on (to coincide with the film's release), and for the PlayStation Portable on October 16, 2007. Spider-Man 3 is a 2007 action-adventure video game based on the Marvel Comics character Spider-Man.

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